from my experience,
treadmills work my calves over a lot more than my normal trail/back road mountain runs. the non-treadmill runs hit my quads and hamstrings a little more.
uphill and downhill running depletes glycogen stores faster (per distance) than level running. / however, what does it
mean that treadmills border/cross-over into the perfect repetitive stress machine? i hardly ever change stride frequency or length or any other biomechanical aspect at all in a 16 mile treadmill run. when i'm off the machine, i don't think i've ever had a chance for a normal footplant (stride length and angle of impact are always being determined by changing terrain). without judgment, what -does- this mean, with respect to performance on the track, on the road, on a cross country course? i'd conjecture that the TM has some advantages for track racing with respect to pacing, breathing, etc. ... unless it moves out of a ball-busting time trial and into a give-and-take race. remember geb saying that for his age, he still had his "laps" (that is, his time trialing ability), but his closing speed was waning. / but, anyhow, i prefer mixing it all up. road, trails, TM, pool running, etc. it keeps the mind fresh, and the advantages to either form usually add-up faster than the disadvantages subtract.
back to the point: without a fan or a way to moderate my body temperature, i sweat profusely and start to overheat on a TM. the heart, obviously, goes into overtime to pump blood from core to surface to reduce internal body temperature. and with the sweat really doing no good -- little evaporation equals little evaporative cooling -- i've noticed a defined cardiac drift on the treadmill. perhaps it -does- take less energy to run a certain distance on a treadmill, but that doesn't mean the body (as a system) perceives it as easier.
which just means that maybe the treadmill isn't as tough on the muscles, but harder on the heart.
which is just to trick out "easy" and "hard." it's not "either/or" it's "both/and." treadmill running isn't EITHER harder OR easier than regular running, it's BOTH harder AND easier. // depending upon what your specific training goal is, you determine the best mode to achieve that.
hrm.