Coronavirus is in California - First case not from known infected person - Sh!t just got real!

Ok, Now it's time to Panic! wrote:

UC Davis Internal Memo

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There’s a leak at UC Davis

I believe it's already here and spreading and has been for weeks/months. The issue is that many people have been sick but not sick enough to go to the hospital. So they aren't tested. They recover. Others are old and infirm and do enter the hosptical, but don't meet the CDC criteria because they haven't traveled. They may have died, but the fatality was blamed on the flu.

I had something real bad about 3 weeks ago that forced me to take two sick days -- haven't taken a sick day in ten years. It wasn't a cold, and I had the seasonal flu shot. So what was it?

Many people traveling over the holidays (including myself), but not to China. But if Chinese were traveling within the 2-3 week window where they are contagious but not showing symptoms, they could have spread it through many major airports, who would ever have known?

My wife a medical professional at a hospital likens it to the flu. If you previously had a weakened immune system (many elderly do) then you’re much more likely to die from it.

So if you already have a disease, I would be concerned about the Virus. If you’re healthy than the chances of you dying are slim to none.

In any case people need to simply wash their hands more.

my 3 cents wrote:

My wife a medical professional at a hospital likens it to the flu. If you previously had a weakened immune system (many elderly do) then you’re much more likely to die from it.

So if you already have a disease, I would be concerned about the Virus. If you’re healthy than the chances of you dying are slim to none.

In any case people need to simply wash their hands more.

Wow. That’s good news. You really should relay this info to the CDC.

I don't believe the Chinese government about anything. This whole Cov 19 virus is probably a cover story to hide the real reason people are dying left & right in China: Toxic Air Pollution!

Outdoor air pollution contributes to the deaths of an estimated 1.1 to 1.6 million people in China every year:

I say again: 1.1 to 1.6 million die every year in China due to their toxic air! Where was the world talking about this years ago? No mainstream media outlets seem give a crap about this. Now there's a few thousands deaths that the Chinese are blaming some virus for - how convenient & sneaky. But yet there's over a million annual deaths from the real problem in China: The toxic deadly air! Their government sure as heck doesn't want to talk about that, so they'll come up with a virus cover story that instills fear globally. People love a scary story with illnesses/sicknesses and viruses are always center stage to scare the heck out of people.

It’s not about the fatalities necessarily (not to downplay) but the change in routine in order to avoid the virus (including extended quarantine) and the duration of treatment.

Apparently now there is recurrence of the illness in people who have “recovered”. Apparently there is not necessarily the development of immunity after exposure. Makes one wonder whether a vaccine will ever be effective.

my 3 cents wrote:

My wife a medical professional at a hospital likens it to the flu. If you previously had a weakened immune system (many elderly do) then you’re much more likely to die from it.

So if you already have a disease, I would be concerned about the Virus. If you’re healthy than the chances of you dying are slim to none.

In any case people need to simply wash their hands more.

"Medical professional" just say her qualification. obviously not a physician and only qualified to speak to a certain depth.

No disease this widespread has close to the severity of CoV-2 for decades.

Primary method of transmission involves respiratory droplets, either directly or on surfaces, where the virus can remain infectious for up to a few weeks. The pandemic effect definitely will impact us.

I was not put at ease last night by President Rambling Dipshat. Obama, the Bushes, Clinton, Reagan, et al. could all convey serious information about serious topics with grace and appropriate authority. Chuckles the Spray Tanned Clown used the opportunity to inform us that the China trade deal is super bigly, that Brazil will be OK because the president of that country is his buddy and ran to "Make Brazil Great Again", and that he personally put Mike Pence in charge because he did such a great job with opioids and methamphetimines as Indiana governor. In fact, his faith based approach to public health made HIV greatly big again in The Hoosier State!

We're boned with these geniuses running the show. Let's see how much the markets drop today.

Everything will be fine..

I yearn for the days before the internet when the only place you all could cause mass panic was standing on a street corner with a sign around your neck.

What was it? Well you clearly had COVID-19. There's no other logical answer. Flu shots are 100% effective and you said it wasn't a cold. That eliminates every other possibilities Timmy. You are patient X.

iwkjsjdjdh wrote:

https://metro.co.uk/2020/02/27/pope-francis-falls-day-supporting-people-coronavirus-12314029/

i lol'd at this hahaha

The BMJ :

" Rapid Response:

Re: China coronavirus: mild but infectious cases may make it hard to control outbreak, report warns

Dear Editor,

Earlier we postulated that ACE inhibitors and/or ARBs (angiotensin II receptor blockers) might be general viral antidotes (PMID: 15379656). ACE (CD143) appears on the macrophage plasma membrane during activation, the macrophage initiates the innate immune response, and many cell types involved in the innate immune response (lymphocytes, neutrophils, etc.) contain angiotensin II type 1 and/or type 2 receptors on their plasma membrane. Inhibiting ACE could therefore attenuate the severity of the "cytokine storm" responsible for morbidity and mortality in viral diseases. This approach may not apply to the herpes viruses, which induce a state of immunosuppression. But losartan, an ARB, seemed to lessen symptoms in humans, horses, and raptors infected with West Nile virus (ref. above and unpublished data).

The SARS coronavirus may offer a 2nd reason for using an ACE inhibitor or ARB (PMC2042929), depending on the patient's blood pressure. The virus binds to host cells via its spike glycoprotein, also called the E2 glycoprotein precursor (Gene ID 1489668; NCBI Accession number NP_828851.1). A peptide sequence within the binding domain (pfam09408, ABE77216) consists of (545)FQPFQQF(551). FQP is an analog of quinapril, an ACE inhibitor.

The cellular receptor for the spike glycoprotein is ACE2 (Gene ID: 59272). Like ACE, ACE2 has the same ancient zinc-binding catalytic site: (374)HEMGH(378). A potential autoinhibitory peptide exists downstream: (523)FQFQ(528). This is similar to ACE, a duplicated enzyme (ACE2 is not duplicated), in which the N-terminal active site has a potential autoinhibitory tripeptide 213 aa's C-terminal to it (FQP), analogous to quinapril, whereas the C-terminal active site has FKP, lisinopril, 213 aa's downstream.

The active site of ACE2 appears to bind both angiotensin II and the SARS coronavirus spike glycoprotein through an FQ-containing motif shared by quinapril. The active site of ACE2 thus resembles the N terminal active site of ACE. In patients lacking the systemic blood pressure for an ACE inhibitor like quinapril, an ARB such as losartan could be substituted as a first approximation, since we found it useful for West Nile virus encephalitis. "

The toxic deadly air creates an inflammatory response in the lungs, and then the COVID-19 virus unleashes a cytokine storm after binding to ACE 2 receptors. The lungs are overwhelmed and the sick die.

They have to stop quarantining people and let us face the inevitable of another virus that kills the weak. Not unlike all of the flu we face every year.

The press and the dumb masses are now going to blow this out of proportion and the economy is likely to come to a halt for no good reason.

I’m at the end of my rope. I am no genius, but I really wish sometimes that I was as dumb as the average person. It would make it a lot easier to accept what is going on.

yes, that is certainly one approach. But the problem with that idea is the death rate. A normal flu kills about 1 out of 1,000 people who get it each year (normally the flu hits 10-40 million Americans - and those who die are mostly the elderly and some very young children). The death rate for this virus is 3%....that means 3 out of every 100 who get it die. Unless the virus weakens or our immunity strengthens that could mean a whole lot of deaths.

i think the death rate could even be higher than 3%. Here the math on that. 2,000 deaths with 80,000 infected. but of the 80,000 who have contracted the virus only a fraction have been "cured". lets say half are recovering. that's means another 2,000 could die from the original pool of infected persons. that could bring the death rate up to 6%.

again a normal flu kills 1 out of 1,000

this kills 1 out of 30 or 3+ per 100.

that ain't good.

Or create a recession.

Wikipedia :

" Cytokine storms have potential to do significant damage to body tissues and organs. If a cytokine storm occurs in the lungs, for example, fluids and immune cells such as macrophages may accumulate and eventually block off the airways, potentially resulting in death. "

So the Chinese get the double or triple whammy if they smoke and breathe polluted air. It would be interesting to see how polluted South Korea and Iran are, and if the effects are the same.