Armstronglivs wrote:
So you need an academic to tell you there's an advantage in testosterone. Of course you do.
No, I want know to what extent testosterone helps people with reduced levels of DHT. Wikipedia says DHT is a "very poor anabolic agent", but doesn't say how testosterone affects people without it.
I was previously under the impression that Caster was unable to properly metabolize any testosterone in her system, but apparently it's more complicated than that. Here's more from Wikipedia:
"Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than testosterone, so that its androgenic potency is about 5 times that of T.[117] The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects."
So if you have some knowledge of how a lack of DHT might affect traits like muscle mass or bone density then I'd be happy to hear from you.