: Proc Natl Acad Sci U S A. 2002 Dec
24;99(26):17215-8. Epub 2002 Dec 05. Related Articles,
Links
An Ethiopian pattern of human adaptation to
high-altitude hypoxia.
Beall CM, Decker MJ, Brittenham GM, Kushner I,
Gebremedhin A, Strohl KP.
Department of Anthropology, Case Western Reserve
University, Cleveland, OH 44106, USA.
cmb2@po.cwru.edu
We describe, in Ethiopia, a third successful pattern
of human adaptation to high-altitude hypoxia that
contrasts with both the Andean "classic"
(erythrocytosis with arterial hypoxemia) and the more
recently identified Tibetan (normal venous hemoglobin
concentration with arterial hypoxemia) patterns. A
field survey of 236 Ethiopian native residents at
3,530 m (11,650 feet), 14-86 years of age, without
evidence of iron deficiency, hemoglobinopathy, or
chronic inflammation, found an average hemoglobin
concentration of 15.9 and 15.0 gdl for males and
females, respectively, and an average oxygen
saturation of hemoglobin of 95.3%. Thus, Ethiopian
highlanders maintain venous hemoglobin concentrations
and arterial oxygen saturation within the ranges of
sea level populations, despite the unavoidable,
universal decrease in the ambient oxygen tension at
high altitude.
PMID: 12471159 [PubMed - indexed for MEDLINE]
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there's lots of data comparing Tibetans and Andes
Indians, but here's the highlights:
This sample of high-altitude native residents from the
Semien Plateau of Ethiopia had hemoglobin
concentrations that differed little from sea level
values. The similar findings of erythropoietin
concentration and oxygen saturation in the normal sea
level range were consistent. The findings would not be
remarkable if this were a sea level sample, but it is
a sample of people exposed to chronic, lifelong
hypobaric hypoxia. Ethiopians must have unique
adaptations of oxygen uptake or delivery that result
in the absence of an hypoxemic stimulus to increase
red blood cell production and hemoglobin concentration
despite their high-altitude residence.
...
The results of this study suggest that Ethiopian
high-altitude natives respond to hypobaric hypoxia
differently than Andean or Tibetan highlanders. This
Ethiopian sample resembles samples from the Tibetan
Plateau in exhibiting little or no elevation of
hemoglobin concentration in this altitude range, but
differs from Tibetans who have very low oxygen
saturation. It differs from Andean high-altitude
natives who exhibited both substantial elevation of
hemoglobin concentration and low oxygen saturation.
These findings suggest there are three patterns of
adaptation to high-altitude hypoxia among indigenous
populations (Table 1). Learning why the three
populations differ will require two lines of future
investigation. One is understanding the biological
mechanisms and the underlying genetics that allow
successful high-altitude adaptation with
quantitatively different suites of traits for oxygen
sensing, response, and delivery. The other is
understanding the evolutionary processes that produced
these patterns to explain how and why several
successful human adaptations to high altitude evolved.
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