So far I've only seen 1 or 2 constructive comments on this thread. Try to have an organized, constructive talk with her about it. Be open to the fact that she might see (correctly or not) your running hobby as symptomatic of something else--some imbalances in the relationship, maybe insecurity on her part, or any number of things really.
Work out a training schedule with her that she can agree with and make sure she knows you (a) will uphold your responsibilities in the household/family; and (b) will spend quality time with her too. The quotes you provided lead me to believe that she doesn't know much about how training works. Maybe you haven't it explained to her adequately. Maybe your training schedule looks or actually IS too erratic for her to see a logic behind it.
I think that there is much good that can come out of an organized discussion with your wife. Maybe your training will become more systematic and efficient. Maybe your goals will be more clearly defined (even if this is just "be fit until I'm in my 70s"). Maybe you will come to realize you have been neglecting something in the relationship, and this will help you be better. Maybe you will decide that 50mpw is not reasonable given all of your responsibilities, and e.g. instead you can periodize your training for a few goal races per year. Lots of possible solutions to this perceived crisis that are not as dire as most people here assume.