"Currently, questions are being asked about the extent to which pharmaceuticals such as AICAR, GW501516, TP500 and GAS6 are being used. Some of them have already been found during searches of vehicles and have been used by some athletes, doctors and soigneurs. These substances provide an equivalent effect to EPO, because they improve the performance of the athlete by boosting the transport and utilisation of oxygen by the body. Their effect is very well known. AICAR and TP500, for example, increases the number of mitochondria in the muscles. These cells are in a way little energy plants, which transform substrates (carbohydrates, lipids, proteins) into energy through the use of oxygen. The two products also bring about an increase in lipolysis (the breakdown of 'fat' to provide energy). They maintain lipolysis during intense efforts."
"To be more specific, when an athlete is tying at 80 per cent of his maximum, in principle he stops burning fat and only burns carbohydrate. By using these products, he can continue to burn fat as well as carbohydrate, even at 95 per cent of his maximum. This additional power, which stems from the use of fat reserves, offers a huge advantage. It is absolutely impossible to achieve naturally. Meanwhile the public can see another effect of the products in the physical transformation of competitors into athletes who don't seem very muscular and are very lean. They have a very low fat percentage because they are able to burn all their fats, including those in muscle fibres, and benefit from an increase in energy. With regard to growth factor GAS6, this allows the secretion of endogenous EPO. It is completely undetectable.”
Here's a quick excerpt from Christopher Basson's new book (he's a retired professional cyclist). I wonder if this is the high tech doping a lot of the teams with money, including runners are doing. Really interesting. A similar situation is happening in comparison to the russian doping scandal in the sense that 5 riders from Astana (the Khazakistan team) have tested positive recently. Some of them being from their feeder team!!