judging by last year's results, this course is either quite technical, the footing really sucked last year, or the elevation change is extreme, because the top times were very, very slow. example is the runner-up ran 5:03 for the 32-mile race, whereas he ran 6:40 at the JFK 50.
based on that, if i were you i would incorporate power hiking steep hills and running as many of your easy runs on hilly, technical trails as you can. one workout that i have found very useful, and that would fit well with your summertime racing at shorter distances, is to do a track workout (e.g., 6-10x800 -- whatever you like to do) and then follow it immediately with fast-hiking repeats up a steep hill. (i can conveniently do this at a nearby high school and state park, which are located half a mile from one another.) the goal is to improve your hiking skills on tired legs.
generally, i would say that 50K training and marathon training are pretty much the same, but you'll need to be ready for more time on your feet if this course is as slow as it seems to be. this doesn't mean you can't enjoy your road or track races this summer, though. i raced my best (and most evenly paced) trail 50 miler in 7:55 (age 48 female, just a week after setting my 10K PR on roads).
my race day advice would be to take the first 2/3 of the race distance at a conversational pace and then give it what you've got for the final 10-or-so miles (*story below). if people around you are hiking a particular hill early in the event, it's probably for a good reason, and you shouldn't tax yourself on it either. also, it's deceptively easy to lose huge amounts of time at aid stations. carry your own bottle(s) or hydration pack and refill (only) as necessary, and don't loiter.
*bonus story: at a local two-loop 50K last year, i chatted with folks around me for the first ten miles (until i left them at an aid station that i didn't need). an hour after the finish, where i had come in 30 seconds behind the winning woman (20 years my junior), one of my previous conversation partners crossed the line (i was then well into my rest-of-the-day duties as finish line timer). she said, "imagine how much faster you could have run if you hadn't chatted all that time," to which i answered, "no. i would have run harder early and finished slower." as it was, i ran precisely even splits for the two loops, but she positive splitted by ~45 minutes. it pays to be conservative and hike if you need to in a tough 50K (or longer). and enjoy the journey.