Thanks Dr. T! I spent most of the day traveling after a trip out to Portland/Eugene trying to get some research momentum going. Good trip, lots to do.
Running is going fine. It has been a little over a year since I started my posts on here - what a year, you'll not see many detailed like that, and I hope we don't.
For the research minded, a couple of interesting tumor blood flow related articles:
http://cancerres.aacrjournals.org/content/53/22/5528.full.pdf
http://www.medizin.uni-tuebingen.de/transfusionsmedizin/institut/eir/content/2006/6/article.pdf
This second one because increased IL-6 can increase release of epinephrine, which can reduce tumor blood flow as per first article. I'm following the idea of not being a workout hero during infusion - keep the intensity & duration moderate, can exercise then dampen an IL-6 response? Interestingly, IL-6 is in the 300-400 pg/mL range when induced by etoposide, a drug I received. If you look at Table 1 you'll see that it takes some long duration (even a 24 hour run) just to get above 100 pg/mL. Did my cycling affect that large spike in IL-6, preventing a decrease in tumor blood flow? Furthermore, Fig. 3 depicts quick clearance of IL-6 after exercise stops, with comments in the first paragraph on page 13.
So, in the paragraph above, it seems as if one were to just sit there and get etoposide, it would cause a big release of IL-6, which would stimulate epinephrine, which can decrease tumor blood flow, which would decrease the perfusion of etoposide within the tumor - reducing efficacy!
And, Adrenal medulla and exercise training
http://www.ncbi.nlm.nih.gov/pubmed/9535578
In this article, according to Fig. 2, trained people who exercise moderately, if not lightly, increase adrenaline (epinephrine) clearance.
Off the soap box now!
Have a nice week all!