OK again, this is a tiring subject because I always seem to be repeating myself and no one seems to read my posts carfeully. I'll try again.
Using an altitude tent/nitrogen house is not the same as training at altitude because:
1. You are only taking one part of the hypoxic high altitude environment (the low oxygen partial pressure) and putting it into a tent. You are not having to deal with all the other entities of a high altitude environment such as climate or terrain etc..
2. The low oxygen partial pressure in a high altitude tent/nitrogen house is obtained by altering the mixture of gases in the air by pumping in more nitrogen. Thus the oxygen/nitrogen ratio of the gases has changed from the 20%/80% ratio that is in atmospheric air. So this gas mixture cannot be described as air. You will be breathing a specific mixture of gases which will be specifically altering the level of EPO in the blood (thus leading to a higher red cell count). How similar is this to taking a drug ?
3. Each individual has a very specific EPO response to hypoxia. It has been known for a long time that different people will respond differently to hypoxia in terms of their EPO response. Linked to this we know also that people respond differently to altitude training at a similar altitude (eg of a study on this: Chapman et al 1998 "Individual variation in response to altitude training" in the Journal of Applied Physiology".) Given that you can precisely control the level of hypoxia in a high altitude tent/nitrogen house, you can set this level to give you as an individual the maximum EPO response. This would be harder to acheive by training at different altitudes because of the climactic factors involved. How similar is breathing this precisely controlled level of hypoxia to taking a drug ?
4. The LATEST research on intermittent hypoxia and human cells shows that intermittent hypoxia of 1hr on 1hr off is giving a bigger induction of genes regulated by hypoxia (such as EPO) compared to continuous hypoxia alone. This is due to a relative upregulation of the transcription factors controlling these genes during intermittent hypoxia. For those of you who say this is BS you are not up date with respect to the field of hypoxia research. There are several papers published and you can read abstracts of these if you do a simple Pub Med search on the internet. For example:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11299293&dopt=Abstract
Should someone start to use an altitude tent using the intermittent hypoxia technique, it is perhaps not unreasonable to suggest that this could give a bigger epo response than just continuous hypoxia alone. Preliminary results from studies done in the laboratory in which I am working do in fact suggest this but they have to be confirmed. This EPO response could not be achieved by an individual simply living and training at altitude.
All of the above are nothing like using shoes, driving a car etc - you are breathing a mixture of gases which is having a specific effect on a physiological pathway which can lead to an improvement in endurance performance.
I mentioned some time ago on this website that the latest generation of drugs that could increase red cell count work by stimulating the kidney itself to produce more EPO and that these were being used on patients with chronic renal disease in the hospital in which I work. Last week a link to some news about the drug 'repoxygen'was put up on this website. This drug works in this way. If used in sports it will be tricky to detect because the drug has a rapid clearance from the body.
So there is one scenario where someone breaths a synthetic hypoxic mixture of gases to increase their EPO production in the kidney and another scenario where someone takes a drug to increase EPO production in the kidney. How similar are the two ? I am not sure but when I consider the latest developments of pharmacology and gene induction I feel that we really are coming into a difficult area of what can be considered as 'legal'or 'illegal'.
If tents are decided as being illegal then I agree it could be difficult to test for them. However we should bear in mind the components of the test for synthetic EPO. There is a direct test which looks at the electophoretic mobility of sythetic EPO which is slightly different from natural EPO because the synthetic EPO has a different overall electric charge. There is also an indirect test which looks at several markers of synthetic EPO abuse in the blood (these include: haematocrit, reticulocyte haematocrit, serum EPO, soluble transferrin receptor, percentage macrocytes).
Perhaps research on these indirect markers could reveal indicators of having used a hypoxic tent/nitrogen house. It is a long shot - but if we consider the latest drugs which are cleared very rapidly from the body then I feel that overall drug testing needs to move towards assessing these indirect markers rather than just trying to test for the drug itself if the tests are to be at all effective in the future.
Hope this is food for thought :)