Jon Orange. wrote:
It's completely unrealistic to expect any increase in mitochondrial density from training.
I would hope by this point, there would be a reasonable expectation to include your sources for such conclusions. Without sources, and this goes for ALL posters... the credibility of your claims are significantly diminished (especially when they're directly challenging the conventional understanding of the subject).
I have a graduate degree in Exercise Physiology, and degree in Sports Psychology... and I'm an endurance coach, with competitive training and racing experience. The convergence of the various disciplines that make up my background would continuously tangle and knot up if I didn't maintain (or work very hard to do so) an objective and practical mindset. I don't always succeed, but it's not from lack of effort.
I've read this entire thread, and found it very interesting, informative, and at times frustratingly childish! Of course the union of intuition and peer review science is (at times) messy, but I also believe the two are not mutually exclusive when it comes to the advancement of knowledge, and the practical application of training for increased exercise performance.
RE: Mitochondrial Density and Exercise Training
I do not have full access to this article yet, so my river is limited... however I found this to be relevant to the discussion, at least in part with respect to (assumed) adaptations to consistent aerobic exercise training over prolonged periods of time (weeks, months, years).
Lundby, Anne-Kristine & Jacobs, Robert & Gehrig, Saskia & de Leur, Jeroen & Hauser, Moritz & Bonne, Thomas & Nowak-Flück, Daniela & Dandanell, Sune & Kirk, Niels & Kaech, Andreas & Ziegler, Urs & Larsen, Steen & Lundby, Carsten. (2017). Exercise training increases skeletal muscle mitochondrial volume density by enlargement of existing mitochondria and not de novo biogenesis. Acta physiologica (Oxford, England). 222. 10.1111/apha.12905.
Method:
Skeletal muscle samples were collected from twenty-one healthy males prior to and following 6 weeks of endurance training.
Result:
MitoVD increased with 55 ± 9% (P < 0.001), whereas the number of mitochondrial profiles per area of skeletal muscle remained unchanged following training. Citrate synthase activity (CS) increased (44 ± 12%, P < 0.001) however, there were no functional changes in oxidative phosphorylation capacity (OXPHOS, CI+IIP ) or cytochrome c oxidase (COX) activity.
Note: Increased volume density (hypertrophy of existing mitochondria), but NOT increased quantity of mitochondria... NO functional changes in oxidative phosphorylation or cytochrome c oxidase activity.
This is just one of many modern studies relating to endurance training and physiological adaptations that may challenge the conventional way of thinking... keep an open mind, keep learning, and respect the debate.