The best wait to reduce muscle mass is simply running more. Even still you may have a hard to near impossible time decreasing their muscle mass. Some people are just not built to run, but that doesn't mean they can't be very successful runners...
Use their muscle mass, their strength, to their advantage. If you can't reduce their muscle mass then increase the STRENGTH and POWER of their muscle mass. You can increase strength and power without increasing muscle size. Increased strength and power without increasing muscle mass leads to a higher strength to weight ratio which will lead to a faster runner, cyclist, etc.
My own personal example is running 4:27/9:32 as an all-state runner in single class Indiana back in '96; running a 1:09:40 half-marathon, 2:32:45 marathon, and 15:43 road 5k. I'm 5'6', 144lbs with 132lbs of fat free mass, 8% body fat. Even running upwards of 100-120 miles a week, averaging 100 miles a week for 12 weeks before that marathon PR, not eating a lot of protein, and not lifting weights, I simply do not lose muscle mass.
My suggestion to use that muscle mass to their advantage is what has worked for me: Plyometrics and dynamic strength training:
1. Double leg hops, single leg hops, box jumps, etc.
2. Squats, lunges, jump squats, split jumps onto a box, jump squats on/off a box
3. Basic strength training exercises: pushups, pullups OR bench press, dumbbell row, 10 rep squats
4. Speed drills, lateral drills, burpees, etc
5. LIGHT power exercises: cleans with just the bar, dumbell thrusters
6. Hills, hills, hills, hills, hills....
7. Run first, preferably on a hard training day, then strength train.
Alan