Look at an extremely pro-mRNA scientist, who gets paid to fear monger, squirm and wiggle. Has to, of course, throw a bone to hybrid immunity, but, significantly, acknowledge that jabs aren’t working as well as they were thought to or as well as natural immunity.
”There are also other factors that come into play providing intrinsic protection (without exposure) vs Covid, with several genomic loci associated with protection, pre-existing T-cells from skin and gut microbiome exposure, and, in some people, preexisting immunity build from common cold coronavirus exposure.”
“Prior infections do clearly play a pivotal role to explain the differences. As we are seeing in Japan currently, where like Australia and New Zealand, there was marked containment of the virus throughout the pandemic until Omicron BA.1 led to a major surge, superseded by a much bigger one with BA.5. The deaths there are still on a sharp rise.”
“No question that population exposure to infections plays a key role, as the people infected with SARS-CoV-2 see the whole virus, not just the spike (as the vaccines provide), and those who also get vaccinated have a potent form of hybrid immunity documented in so many studies.”
“A similar story may help explain the United States handling BA.5 better than may have been predicted from countries in Europe (such as Portugal, Greece, France, UK, Denmark, and others). It uniquely had a major wave of the BA.2.12.1 variant which shares a key spike mutation with BA.4/5 in L452 (Q instead of R) that is not seen in BA.1 or BA.2. The L452 mutation is one that was tied to the biologic properties of Delta, which included its higher pathogenicity. Like the Beta variant mass exposure in South Africa, BA.2.12.1 likely provided some cross-immunity for the subsequent BA.5 wave in the United States.”
“To summarize, the impact of BA.5 that I have described as the worst variant of the pandemic by its biologic properties is seen clinically where there are less intact immunity walls, mostly as a function of prior infections and the type (main variant underpinning) of infections. Our immunity wall in the United States has helped provide a lesser hit of BA.5, now starting to show a plateau of hospitalizations at a level below that of other countries in Europe, even though our vaccination and booster rate in the US is substantially lower than these countries.”