I specialize in dumb comments. wrote:
Yes. I realize that it helps transport medicine through cell walls, but the OP is implying that DMSO works on its own. What is the mechanism that DMSO (a solvent) uses to help sore muscles?
Elisia et al 2016:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816398/Herein, we demonstrate that DMSO has ex-vivo anti-inflammatory activity using Escherichia coli- (E. coli) and herpes simplex virus-1 (HSV-1)-stimulated whole human blood. Specifically, we found that between 0.5%– 2%, DMSO significantly suppressed the expression of many pro-inflammatory cytokines/chemokines and prostaglandin E2 (PGE2). However, a significant reduction in monocyte viability was also observed at 2% DMSO, suggesting a narrow window of efficacy. Anti-inflammatory concentrations of DMSO suppressed E. coli-induced ERK1/2, p38, JNK and Akt phosphorylation, suggesting DMSO acts on these signaling pathways to suppress inflammatory cytokine/chemokine production. "
My guess is that the anti-inflammatory effects of DMSO are probably related to its toxicity - i.e. it prevents cells from producing their normal inflammation signals by damaging them.