Sydney McLaughlin ran 50.97 to move to #3 all-time Under 20 only behind Sanya Richards-Ross and Shaunae Miller-Uibo.
Penn leads with Harvard, Dartmouth and Princeton close behind.
They have a 30 point lead on Brown in second.
Freshman Fiona O'Keeffe ran 9:04 to win the 3k and Olivia Baker took the 800 in 2:04.31 and also anchored the winning 4x400.
Neither competition was even close as both USC teams won by over 20-points.
Knight ran 8:02 to make it another Syracuse 1-2 as Aidan Tooker was 2nd (8:04).
Virginia Tech men and women were both runner-ups, losing by just 4 points on the men's side.
Marquette was a close 2ne in a both races.
2017 NCAA outdoor runner-up Isaiah Harris won the 800 (1:50.15) while both Wisconsin's Oliver Hoare and Indiana's Katherine Receveur completed successful 3k/5k doubles.
They got wins in the SP, LJ, PV, 200, and 4x400 to beat Nebraska by 8-points.
They beat runner-up Kansas by 5-points.
She broke the previous record of 9:10.48 by Cory McGee from 2014.