I don't think you're going to find one single thing that could have changed the outcome of so many in this race. Rather, they had unique conditions that, when combined with other unique factors (which on their own may not have been so disastrous), led to so many DNFs. Clothing choices, skipping food, dropping bottles, sticking your nose out in the wind, running "easy" etc.
Galen dropped a bottle, Shalane said she stopped eating, Molly seemed to always have her head out in the wind (even running in the pack she was off the side and exposed), Kirui's jacket and sitting in the wind alone. Desi spent more time in the pack protected than she did alone in the elements. When Yuki was off the front exposed he was hammering and then he tucked into the back of the pack protected. AJ dressed like he was on the beach in Cabo without negative effects but he, for the most part, stayed out of the wind.
It would be interesting to know what the fueling was for the front runners and if they stayed on track, increased, or it fell off because of the pace and the conditions. I've run the latter half of a 100 miler in sub freezing temps with big wind and it's pretty easy to talk yourself out of eating or drinking anything.
Anyway, I'm not here to play armchair quarterback but it's a very interesting case study.
Also, I've mentioned it in the clothing threads but I'll say it again here. For anyone that thinks they may have to run in some cold, windy, rainy elements it's extremely worthwhile to check out some of the new 1-layer GoreTex offerings that are out there. Wind and waterproof yet unlike their 2 and 3 layer counterparts they are crazy breathable. Arcteryx makes on in the Norvan SL (I have this jacket and love it) and North Face currently offers one as well in the Hyperair GTX.