WTFBBQ wrote:
ukathleticscoach wrote:
Anyone else fail a test after eating burgers? Millions of people including athletes eat burgers how come they are not failing tests
She's as clean as Contador.
Are we seriously going through this again?
There are LOTS of people who have tested positive for PEDs through contaminated meat. Look up the junior Pan Am Games a few years back.
USADA announced today that Ajee Wilson of Philadelphia, Pa., has tested positive for a prohibited substance, which was determined to have been ingested by her WITHOUT fault or negligence.
Wilson, 23, provided a urine sample on February 11, 2017, at the NYRR Millrose Games in New York, NY. Her sample tested positive for zeranol. Zeranol is an Anabolic Agent prohibited at all times under the USADA Protocol for Olympic and Paralympic Movement Testing, the United States Olympic Committee National Anti-Doping Policies, and the International Association of Athletics Federations, all of which have adopted the World Anti-Doping Code and the World Anti-Doping Agency Prohibited List.
During its investigation into the circumstances that led to the positive test, USADA gathered evidence from Wilson, which included reviewing her dietary habits and food purchase receipts. USADA also took into consideration laboratory reports demonstrating low parts per billion (ppb) concentrations of the prohibited substance in her urine, as well as the fact that she tested negative one week prior.
USADA further relied on reports from multiple independent experts on zeranol in the food supply and environment, including the use of zeranol as a legal growth promotant in beef cattle in the U.S. Based on the totality of the evidence, USADA concluded it was highly unlikely that the presence of zeranol in Wilson’s sample resulted from a source other than zeranol contaminated meat.
Zeranol (INN, USAN, BAN) (brand names Frideron, Ralabol, Ralgro, Ralone, Zerano; developmental code names MK-188, P-1496), or zearanol, also known as α-zearalanol or simply zearalanol, is a synthetic nonsteroidal estrogen of the resorcylic acid lactone group related to mycoestrogens found in fungi in the Fusarium genus.
Zeranol is approved for use as a growth promoter in livestock, including beef cattle, under the brand name Ralgro (by Merck Animal Health) in the United States. In Canada, it is approved for use in beef cattle only.[5] Its application is not approved for use in the European Union. However, it is marketed under the brand name Ralone in Spain.[2]
Dietary exposure from the use of zeranol-containing implants in cattle is usually insignificant.
Zeranol may also be found as a contaminant in fungus-infected crops which are used in animal feed and fed to cattle.
Food Chem Toxicol. 1985 Aug;23(8):767-74.
Zeranol--a 'nature-identical' oestrogen?
Lindsay DG.
Abstract
The use of implants of zeranol (alpha-zearalanol), a widely-used anabolic growth promoter, in food animals results in very low residues of this compound in the edible tissues. In comparison, residues of myco-oestrogens--specifically the beta-resorcylic acid lactones (RALs) such as zearalenone and its metabolites--commonly found as contaminants of cereals are MUCH GREATER.
Zeranol, the RALs and their metabolites are all closely related chemically, sterically and biologically. The biological effects of these compounds on reproduction, oestrogenicity, teratogenicity, genotoxicity and carcinogenicity are compared. No toxicological effects have been reported that cannot be attributed to the estrogenic character of these molecules.
In comparison with estradiol, zeranol and the related myco-estrogens are 100-1000 times LESS ACTIVE hormonally.
It is concluded that a likely no-observed-effect level (NOEL) for these compounds will be of the order of 0.05-0.1 mg/kg body weight/day. This would result in a safety margin greater than 500-fold between the expected dietary exposure to these compounds (considered together) and the likely NOEL. On the basis of exposure to zeranol alone, this margin of safety would increase to more than 35,000.
Estrogens are also not a good choice as a veterinary drug to use for human doping as a performance-enhancing drug.
Zeranol would not be a good choice as a veterinary drug to use for human doping as a PED.
(Ajee Wilson also had a level of zeranol in her urine that was measured at a level that was in parts per billion.)
Ms. Ajee Wilson is the clean U.S. Record holder in the 800m with a time of 1:55.61 and won the Bronze medal at the 2017 World Championships.
Ms. Ajee Wilson is also a new World Record holder in the indoor 4 X 800m:
http://cdn.letsrun.com/wp-content/uploads/2018/02/Wilson_Ajee_Lipsey_Charlene_With_Team_4x800_WR_MRG_2018_Jane_Monti.jpgOh yeah.
