We all know the given ped, e.g. EPO, steroids. The question about new methods and chemicals that e.g. enhance a persons endocrine response to training might be worthy of examination. There are new studies conducted for example, depression such as Norex where chemical compounds are not available for the general public; however are for researchers in academic settings. No doubt that any well placed " researcher" may be able to cut corners with available, but restricted compounds to enhance the status of his or her athlete and claim innocence considering the new compounds are not screened.