For the OP -
Here is one way to approach your subject. You can discuss the ways in which diseases have become modified by changes in society since the middle ages.
Plague is disease everyone associates with this time period. It was a horrible scourge and the epidemics were caused by crowding, terrible public hygiene, ignorance of the cause, and lack of treatment options.
Plague still exists but not in epidemic form - it is endemic in the prairie dog population in the southwest, but there are only sporadic and isolated human cases.
Interestingly, polio existed in ancient and medieval times bit was not epidemic until modern times, i.e. the epidemics began in the early 20th century as a consequence of improved sanitation and hygiene. In medieval times, the virus was prevalent and babies were exposed very early, when maternal antibodies were present and offered substantial protection. However, with modern sewers, clean water supplies, etc, this early exposure ceased and people reached childhood with no exposure. They were then highly vulnerable if exposed, and epidemics of paralytic disease ensued.
So, 2 diseases, both affected by public hygiene, but with totally different natural histories. Good stuff.
A big problem with just writing about medieval conditions with strange names is that many conditions were poorly characterized in those days. Someone mentioned dropsy. Well, they thought dropsy was a disease. It is not. It is what we call edema - swelling due to tissue fluid. It is associated with many diseases - kidney failure, heart failure, sepsis, etc but is not a disease in and of itself. There are many other similar examples.