I ran 22 in 3:15 as part of a 54 mile week, 5 weeks out from my goal marathon. I had done three 20 milers, a 19 miler, and three 18-mile runs in the three months before that.
One week after the 22 I set my master's PR in a half marathon (1:31 low; 6:58 pace). Then I got stupid and ran 21 the week after the half marathon, with a 12-mile fast finish tempo run (10@7:30 + 7:00 and 6:30. An idiotic thing to do. That was my peak.
On race day I felt flat. I was only able to hold 8:00 pace. I finished in 1:31:59 and BQd by one second. That is plainly a sub-par marathon when put next to my half marathon time. I should have been able to run 7:45s without too much trouble.
I don't think you really need 22, this time around. If you do it, run the first half very relaxed, at 70% of max HR or so. Run the second half moderate if you feel good, with a couple of MP miles at the very end if you're really feeling good. But don't push it more than that. Otherwise you're trying to combine too many things. 22 at this point in your cycle is to support the fullest possible expansion of your glycogen storage capacity and to push back the psychological threshold that can accompany the 20-mile "barrier." You're not really trying to do anything beyond that. Do NOT try to combine 22 with substantial marathon pace running, given the training you've put in.